Added: Stephanos Babbitt - Date: 09.07.2021 02:41 - Views: 28465 - Clicks: 9548
The experiments presented here assess the contribution of T cells to NK cell regulation and transforming growth factor-beta TGF-beta production. T cell-deficient mice exhibited high NK cell activity for longer periods of time post-infection. To determine whether the reduction in NK cell activation at later times post-infection of normal mice resulted from induction of negative regulatory elements, mice were treated with the chemical IFN and NK cell inducing agent polyinosinic-polycytidylic acid poly I:C.
In vivo expression of TGF-beta protein in normal and T cell-deficient mice was evaluated by immunohistochemical studies on splenic sections. TGF-beta proteins were not detected in sections from uninfected mice but were induced in all strains during infection.
High levels of TGF-beta proteins were localized to discrete cells, and diffuse staining was observed along marginal zones. The ability of the splenic leukocytes to release TGF-beta into conditioned media was evaluated in the Mv 1 Lu biologic assay. Transient acid treatment to release active factor from the latent form and use of specific neutralizing antibodies demonstrated that leukocytes from all strains of infected mice had released latent TGF-beta 1 into conditioned media.
Treatment with active TGF-beta 1 reduced the s of NK cells per spleen in infected nude mice to the levels found in infected littermate controls. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Display options Display options. Create file Cancel. citation Subject: 1 selected item: - PubMed. Format: Summary Summary text Abstract Abstract text.
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Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract The experiments presented here assess the contribution of T cells to NK cell regulation and transforming growth factor-beta TGF-beta production. Similar articles A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. Su HC, et al.
J Immunol. PMID: NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. Salazar-Mather TP, et al. Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection. McIntyre KW, et al. J Exp Med. Yin S, et al. Parasite Immunol. PMID: Review. Role of NK cells and TGF-beta in the regulation of T-cell-dependent antibody production in health and autoimmune disease.
Horwitz DA, et al. Microbes Infect. See all similar articles. Cited by 16 articles Memory responses of innate lymphocytes and parallels with T cells. Rapp M, et al. Semin Immunopathol. Epub May Sanjabi S, et al. Cold Spring Harb Perspect Biol. Lewis GM, et al. J Virol. Epub Jan Ruiz AL, et al. Nat Commun. Regulation of mouse NK cell development and function by cytokines.
Front Immunol. See all "Cited by" articles. Publication types Comparative Study Actions. Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, P. MeSH terms Animals Actions. Leukocyte Count Actions. Lymphocyte Activation Actions. Male Actions. Mice Actions. Mice, Inbred C3H Actions. Mice, Nude Actions. Substances Transforming Growth Factor beta Actions. Poly I-C Actions. Full text links [x] HighWire. Copy Download.Tgf nudes
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